Botanical Name : Coleus forskohlii 
Sanskrit Name: Makandi
English Name : Coleus
Family : Lamiaceae

Plant Parts Used : Roots

Description Coleus forskohlii :
This species is a perennial herb with fleshy, fibrous roots that grows wild in the warm subtropical temperate areas in India, Burma and Thailand. It is one of the 150 coleus species, which are commonly cultivated as ornamental plants, because of their colorful foliage. The roots of C. forskohlii, unlike other coleus species, are used for health purposes.
 

Traditional uses :
The leaves are used in the treatment of stomach ailments, people chew fresh roots to relieve abdominal pains. They are reported to kill intestinal worms. A few drops of roots extract mixed with milk is given to infants as a remedy against abdominal pains and constipation

Phytochemistry:
The major bioactive constituent of Coleus forskohlii is forskolin, a diterpene. Other diterpenes of the roots include deacetylforskolin 1,9-dideoxy forskolin 1,9-dideoxy-7-deacetylforskolin, coleol etc. The roots contain volatile oil comprising of a-thujene, a and ß-pinenes, camphene, myrcene, 3-nonanone, p-cymene , b-phellandrene, 3-decanone, a-copaene, bornyl acetate, humulene, a-cis-bergamotene, a -curcumene, g-curcumene, ß-bisabolene, ß-elemene, d-selinene,cuparene and a and ß-ionones.

Pharmacology :
"Forskolin's basic mechanism of action is that it activates the enzyme adenylate cyclase and other important chemicals in the body. This results in activatation of a “second messenger” system that is responsible for carrying out the complex and powerful effects of hormones in the body.

This leads to the following effects:

1. Cardiovascular system:
   1. Relaxation of the arteries and other smooth muscles, ie blood vessel dilation
   2. Increased force of contraction of the heart muscle

1. Endocrine system:
   1. Increased insulin secretion.
   2. Increased thyroid function (and therefore metabolic rate).
2. Others:
   1. Inhibition of allergic reactions
   2. Inhibition of the pro-inflammatory substance known as platelet-activating factor (PAF) and inhibition of the spread of cancer cells.
   3. Reduced adipose assimilation and increased lipolysis of fats.

Major constituents: Forskolin

Main action: Anti-glaucoma, Anti-platelet, Bronchospasmolyltic, Cardiotonic, Hypotensive, Anti aging, Anti allergic, Smooth muscle and arterial relaxant, Antiasthmatic.

Main use:

• Coleus is found to be effective in skin conditions as eczema and psoriasis.
• Coleus is mainly indicated in cardiovascular diseases like hypertension, congestive heart failure and angina.
• Studies have indicated the use of coleus for asthma, intestinal colic, uterine cramps, as well as painful urination.
• Coleus can aid in weight loss due to its ability to breakdown stored fat as well as inhibit the synthesis of adipose tissue, additionally, it increases thyroid hormone production and release thereby increasing metabolism.
• Ophthalmic preparation of forskolin to the eyes lowers eye pressure thus reducing the risk of Glaucoma.
• Coleus can aid in digestive and malabsorption disorders through its ability to stimulate secretion of saliva, hydrochloric acid, pepsin, amalyase and pancreatic enzymes and increase nutrient absorption in the small intestine.
• Sports nutrition, Weight management, Lean body mass development

Herbal Extract Packing:
25 kg HDPE Drum